Tau Therapeutics(美國)

Tau Therapeutics

美國TauTherapeuticswww.tautherapeutics.com研發(fā)的T型鈣通道阻滯劑米貝拉地爾（mibefradil）用于實體腫瘤的治療。TauTherapeuticsisdevelopingoncologydrugsforsolidtumorsthatselectivelyinhibittheT-typecalciumchannel.Thecompany’sappr oach,calledInterlacedTherapy™,capitalizesonthecentralroleofcalciuminfluxthroughT-typecalciumchannelsduringcancercellgrowth.T-typecalciumchannelblockadewithTau’sdrugsarreststumorcellsattheirmostvulnerablemetabolicpointinthecellcycle,uniquelyamplifyingtheeffectsofconventionaltherapiesandovercomingdrugresistance.Tau’sfirstproduct,mibefradil,hasbeenusedextensivelyinhumansanditssafetyprofileiswellknown.MibefradilisnowenteringclinicaltrialsforbraincancerwithsupportfromtheNCI.TauTherapeuticsisaprivatecompanybasedinCharlottesville,VA.